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產(chǎn)品詳情
  • 產(chǎn)品名稱:Anti-FER antibody (200-450) (STJ111789)

  • 產(chǎn)品型號:STJ111789
  • 產(chǎn)品廠商:ST john's laboratory
  • 產(chǎn)品文檔:
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簡單介紹:
Anti-FER antibody (200-450) (STJ111789)
詳情介紹:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FER (200-450) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FER
Gene ID: 2241
Uniprot ID: FER_HUMAN
Immunogen Region: 200-450
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human FER (NP_005237.2).
Immunogen Sequence: YDITLPLLLDSLQKMQEEMI KALKGIFDEYSQITSLVTEE IVNVHKEIQMSVEQIDPSTE YNNFIDVHRTTAAKEQEIEF DTSLLEENENLQANEIMWNN LTAESLQVMLKTLAEELMQT QQMLLNKEEAVLELEKRIEE SSETCEKKSDIVLLLSQKQA LEELKQSVQQLRCTEAKFSA QKELLEQKVQENDGKEPPPV VNYEEDARSVTSMERKERLS KFESIRHSIAGIIRSPKSA
Tissue Specificity Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
Post Translational Modifications Autophosphorylated. Polyubiquitinated.this leads to proteasomal degradation.
Function Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
Protein Name Tyrosine-Protein Kinase Fer
Feline Encephalitis Virus-Related Kinase Fer
Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer
Proto-Oncogene C-Fer
Tyrosine Kinase 3
P94-Fer
Database Links Reactome: R-HSA-1433557
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Cell Junction
Membrane
Nucleus
Cell Cortex
Associated With The Chromatin
Detected On Microtubules In Polarized And Motile Vascular Endothelial Cells
Colocalizes With F-Actin At The Cell Cortex
Colocalizes With Pecam1 And Ctnnd1 At Nascent Cell-Cell Contacts
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Fer antibody
Anti-Feline Encephalitis Virus-Related Kinase Fer antibody
Anti-Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer antibody
Anti-Proto-Oncogene C-Fer antibody
Anti-Tyrosine Kinase 3 antibody
Anti-P94-Fer antibody
Anti-FER antibody
Anti-TYK3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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