產(chǎn)品詳情
簡(jiǎn)單介紹:
Anti-FCGR2B antibody (241-310) (STJ29692)
詳情介紹:
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-FCGR2B (241-310) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | FCGR2B |
Gene ID: | 2213 |
Uniprot ID: | FCG2B_HUMAN |
Immunogen Region: | 241-310 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 241-310 of human FCGR2B (NP_003992.3). |
Immunogen Sequence: | VVALIYCRKKRISALPGYPE CREMGETLPEKPANPTNPDE ADKVGAENTITYSLLMHPDA LEEPDDQNRI |
Tissue Specificity | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B Igg Fc Receptor Ii-B Cdw32 Fc-Gamma Rii-B Fc-Gamma-Riib Fcrii-B Cd Antigen Cd32 |
Database Links | Reactome: R-HSA-198933 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B antibody Anti-Igg Fc Receptor Ii-B antibody Anti-Cdw32 antibody Anti-Fc-Gamma Rii-B antibody Anti-Fc-Gamma-Riib antibody Anti-Fcrii-B antibody Anti-Cd Antigen Cd32 antibody Anti-FCGR2B antibody Anti-CD32 antibody Anti-FCG2 antibody Anti-IGFR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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