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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546)

  • 產(chǎn)品型號(hào)：STJ70546-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546)
詳情介紹：
Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Cdc42-binding kinase alpha (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75μg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CDC42BPA
Gene ID: 8476
Uniprot ID: MRCKA_HUMAN
Immunogen Region: N-Term
Accession Number: NP_055641.3; NP_003598.2
Specificity: This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).
Immunogen Sequence: SGEVRLRQLEQFI
Post Translational Modifications Proteolytically cleaved by caspases upon apoptosis induction. The cleavage at Asp-478 by CASP3 increases its kinase activity (in vitro).
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells.
Protein Name Serine/Threonine-Protein Kinase Mrck Alpha
Cdc42-Binding Protein Kinase Alpha
Dmpk-Like Alpha
Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Alpha
Mrck Alpha
Myotonic Dystrophy Protein Kinase-Like Alpha
Database Links Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Cellular Localisation Cytoplasm
Cell Projection
Lamellipodium
Displays A Dispersed Punctate Distribution And Concentrates Along The Cell Periphery
Especially At The Leading Edge And Cell-Cell Junction
This Concentration Is Ph-Domain Dependent
Localizes In The Lamellipodium In A Fam89b/Lrap25-Dependent Manner
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Mrck Alpha antibody
Anti-Cdc42-Binding Protein Kinase Alpha antibody
Anti-Dmpk-Like Alpha antibody
Anti-Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Alpha antibody
Anti-Mrck Alpha antibody
Anti-Myotonic Dystrophy Protein Kinase-Like Alpha antibody
Anti-CDC42BPA antibody
Anti-KIAA0451 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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