產(chǎn)品詳情
簡單介紹：
Anti-EPHB4 antibody [5B5] (STJ98036)
詳情介紹：
| Host: | Mouse |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Ephrin type-B receptor 4 is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 5B5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPHB4 |
| Gene ID: | 2050 |
| Uniprot ID: | EPHB4_HUMAN |
| Specificity: | EphB4 Monoclonal Antibody detects endogenous levels of EphB4 protein. |
| Immunogen: | Purified recombinant extracellular fragment of human EphB4 fused with hIgGFc tag expressed in HEK293 cell line. |
| Post Translational Modifications | Phosphorylated.autophosphorylation is stimulated by EFNB2. |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. |
| Protein Name | Ephrin Type-B Receptor 4 Hepatoma Transmembrane Kinase Tyrosine-Protein Kinase Tyro11 |
| Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-3928662 Reactome: R-HSA-3928664 Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Ephrin Type-B Receptor 4 antibody Anti-Hepatoma Transmembrane Kinase antibody Anti-Tyrosine-Protein Kinase Tyro11 antibody Anti-EPHB4 antibody Anti-HTK antibody Anti-MYK1 antibody Anti-TYRO11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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