產(chǎn)品詳情
簡(jiǎn)單介紹：
Anti-DUSP6 antibody (282-381) [S0MR] (STJ11101230)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-DUSP6 (282-381) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DUSP6 |
| Gene ID: | 1848 |
| Uniprot ID: | DUS6_HUMAN |
| Immunogen Region: | 282-381 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 282-381 of human DUSP6 (Q16828). |
| Immunogen Sequence: | ARGKNCGVLVHCLAGISRSV TVTVAYLMQKLNLSMNDAYD IVKMKKSNISPNFNFMGQLL DFERTLGLSSPCDNRVPAQQ LYFTTPSNQNVYQVDSLQST |
| Tissue Specificity | Expressed in keratinocytes (at protein level). |
| Function | Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6 Dual Specificity Protein Phosphatase Pyst1 Mitogen-Activated Protein Kinase Phosphatase 3 Map Kinase Phosphatase 3 Mkp-3 |
| Database Links | Reactome: R-HSA-112409 Reactome: R-HSA-202670 Reactome: R-HSA-5675221 Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibody Anti-Dual Specificity Protein Phosphatase Pyst1 antibody Anti-Mitogen-Activated Protein Kinase Phosphatase 3 antibody Anti-Map Kinase Phosphatase 3 antibody Anti-Mkp-3 antibody Anti-DUSP6 antibody Anti-MKP3 antibody Anti-PYST1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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