產(chǎn)品詳情
簡(jiǎn)單介紹:
Anti-DNAJC5 antibody (131-180 aa) (STJ92500)
詳情介紹:
Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-DnaJ homolog subfamily C member 5 (131-180 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DNAJC5 |
Gene ID: | 80331 |
Uniprot ID: | DNJC5_HUMAN |
Immunogen Region: | 131-180 aa |
Specificity: | CSP Polyclonal Antibody detects endogenous levels of CSP protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human DNAJC5 at the amino acid range 131-180 |
Post Translational Modifications | Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58. This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions. Palmitoylated. Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17. Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment. |
Function | Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. |
Protein Name | Dnaj Homolog Subfamily C Member 5 Ceroid-Lipofuscinosis Neuronal Protein 4 Cysteine String Protein Csp |
Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-888590 Reactome: R-HSA-9662360 |
Cellular Localisation | Cytoplasm Cytosol Membrane Lipid-Anchor Cytoplasmic Vesicle Secretory Vesicle Chromaffin Granule Membrane Melanosome Cell Membrane The Association With Membranes Is Regulated By Palmitoylation Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 5 antibody Anti-Ceroid-Lipofuscinosis Neuronal Protein 4 antibody Anti-Cysteine String Protein antibody Anti-Csp antibody Anti-DNAJC5 antibody Anti-CLN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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