產(chǎn)品詳情
簡單介紹：
Anti-F11R antibody (28-238) (STJ23594)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-F11R (28-238) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | F11R |
| Gene ID: | 50848 |
| Uniprot ID: | JAM1_HUMAN |
| Immunogen Region: | 28-238 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_058642.1). |
| Immunogen Sequence: | SVTVHSSEPEVRIPENNPVK LSCAYSGFSSPRVEWKFDQG DTTRLVCYNNKITASYEDRV TFLPTGITFKSVTREDTGTY TCMVSEEGGNSYGEVKVKLI VLVPPSKPTVNIPSSATIGN RAVLTCSEQDGSPPSEYTWF KDGIVMPTNPKSTRAFSNSS YVLNPTTGELVFDPLSASDT GEYSCEARNGYGTPMTSNAV RMEAVERNVGV |
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Protein Name | Junctional Adhesion Molecule A Jam-A Junctional Adhesion Molecule 1 Jam-1 Platelet F11 Receptor Platelet Adhesion Molecule 1 Pam-1 Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2173791 Reactome: R-HSA-420029 |
| Cellular Localisation | Cell Junction Tight Junction Cell Membrane Single-Pass Type I Membrane Protein Localized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule A antibody Anti-Jam-A antibody Anti-Junctional Adhesion Molecule 1 antibody Anti-Jam-1 antibody Anti-Platelet F11 Receptor antibody Anti-Platelet Adhesion Molecule 1 antibody Anti-Pam-1 antibody Anti-Cd Antigen Cd321 antibody Anti-F11R antibody Anti-JAM1 antibody Anti-JCAM antibody Anti-UNQ264 antibody Anti-PRO301 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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