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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human DAF/CD55 protein (Recombinant) (C-His) (STJP002674)

  • 產(chǎn)品型號(hào)：STJP002674
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human DAF/CD55 protein (Recombinant) (C-His) (STJP002674)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human DAF/CD55-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Measured by its binding ability in a functional ELISA. Immobilized Human DAF/CD55 at 0.5 Mu g/mL (100 Mu L/well) can bind Human CD97 with a linear range of 0.3-23.8 ng/mL.2.Measured by its binding ability in a functional ELISA. Immobilized APC anti
Gene Symbol: CD55
Gene ID: 1604
Uniprot ID: DAF_HUMAN
Immunogen Region: Asp35-Ser353
Immunogen: Recombinant Human CD55/DAF Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp35-Ser353) of human CD55/DAF (Accession #NP_000565.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications The Ser/Thr-rich domain is heavily O-glycosylated.
Function This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21.
Protein Name Complement Decay-Accelerating Factor
Cd Antigen Cd55
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-6798695
Reactome: R-HSA-6807878
Reactome: R-HSA-977606
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cell Membrane
Lipid-Anchor
Gpi-Anchor
Isoform 3: Secreted
Isoform 4: Secreted
Isoform 5: Secreted
Isoform 6: Cell Membrane
Isoform 7: Cell Membrane
Alternative Protein Names Complement Decay-Accelerating Factor protein
Cd Antigen Cd55 protein
CD55 protein
CR protein
DAF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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