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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-Acetyl-Smad2/3-Lys19 antibody (STJ193230)

  • 產(chǎn)品型號(hào)：STJ193230
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-Acetyl-Smad2/3-Lys19 antibody (STJ193230)
詳情介紹：
Host: Rabbit
Applications: IHC/IF/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Acetyl-Mothers against decapentaplegic homolog 2 and Mothers against decapentaplegic homolog 3-Lys19 is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
WB 1:500-2000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SMAD2
SMAD3
Gene ID: 4087
4088
Uniprot ID: SMAD2_HUMAN
SMAD3_HUMAN
Specificity: This antibody detects endogenous acetyl levels of Smad2/3 (Acetyl-Lys19) at Human:K19, Mouse:K19, Rat:K19
Immunogen: Synthesized peptide derived from the human Smad2/3 (Acetyl-Lys19)
Post Translational Modifications Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation.which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1. In response to TGF-beta, ubiquitinated by NEDD4L.which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover. Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo. Acetylation in the nucleus by EP300 is enhanced by TGF-beta.
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Protein Name Mothers Against Decapentaplegic Homolog 2
Mad Homolog 2
Mothers Against Dpp Homolog 2
Jv18-1
Mad-Related Protein 2
Hmad-2
Smad Family Member 2
Smad 2
Smad2
Hsmad2
Database Links Reactome: R-HSA-1181150
Reactome: R-HSA-1502540
Reactome: R-HSA-2173788
Reactome: R-HSA-2173789
Reactome: R-HSA-2173795
Reactome: R-HSA-2173796
Reactome: R-HSA-3304356
Reactome: R-HSA-3311021
Reactome: R-HSA-3315487
Reactome: R-HSA-3656532
Reactome: R-HSA-452723
Reactome: R-HSA-5689880
Reactome: R-HSA-9615017
Reactome: R-HSA-9617828
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic And Nuclear In The Absence Of Tgf-Beta
On Tgf-Beta Stimulation
Migrates To The Nucleus When Complexed With Smad4
On Dephosphorylation By Phosphatase Ppm1a
Released From The Smad2/Smad4 Complex
And Exported Out Of The Nucleus By Interaction With Ranbp1
Localized Mainly To The Nucleus In The Early Stages Of Embryo Development With Expression Becoming Evident In The Cytoplasm At The Blastocyst And Epiblast Stages
Alternative Antibody Names Anti-Mothers Against Decapentaplegic Homolog 2 antibody
Anti-Mad Homolog 2 antibody
Anti-Mothers Against Dpp Homolog 2 antibody
Anti-Jv18-1 antibody
Anti-Mad-Related Protein 2 antibody
Anti-Hmad-2 antibody
Anti-Smad Family Member 2 antibody
Anti-Smad 2 antibody
Anti-Smad2 antibody
Anti-Hsmad2 antibody
Anti-SMAD2 antibody
Anti-MADH2 antibody
Anti-MADR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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