產(chǎn)品詳情
簡單介紹：
Anti-ACO1 antibody (100-200) (STJ27804)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-IREB1 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACO1 |
| Gene ID: | 48 |
| Uniprot ID: | ACOHC_HUMAN |
| Immunogen Region: | 100-200 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Aconitase 1 (ACO1) (P21399). |
| Immunogen Sequence: | MRDAVKKLGGDPEKINPVCP ADLVIDHSIQVDFNRRADSL QKNQDLEFERNRERFEFLKW GSQAFHNMRIIPPGSGIIHQ VNLEYLARVVFDQDGYYYPD S |
| Function | Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA. Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. |
| Protein Name | Cytoplasmic Aconitate Hydratase Aconitase Citrate Hydro-Lyase Ferritin Repressor Protein Iron Regulatory Protein 1 Irp1 Iron-Responsive Element-Binding Protein 1 Ire-Bp 1 |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Cytoplasmic Aconitate Hydratase antibody Anti-Aconitase antibody Anti-Citrate Hydro-Lyase antibody Anti-Ferritin Repressor Protein antibody Anti-Iron Regulatory Protein 1 antibody Anti-Irp1 antibody Anti-Iron-Responsive Element-Binding Protein 1 antibody Anti-Ire-Bp 1 antibody Anti-ACO1 antibody Anti-IREB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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