產(chǎn)品詳情
簡單介紹：
D4S234E Blocking Peptide for STJ501974 peptide (STJ505538)
詳情介紹：
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | D4S234E Blocking Peptide for STJ501974 is synthetically produced from the 140-190 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Nsg1 |
| Gene ID: | 25247 |
| Uniprot ID: | NSG1_RAT |
| Immunogen Region: | 140-190 |
| Specificity: | This blocking peptide is recommended for use in combination with D4S234E antibody, STJ501974 |
| Immunogen: | Synthetic peptide taken within amino acid region 140-190 on human Neuron-specific protein family member 1. |
| Tissue Specificity | Widely expressed in brain and spinal cord. Expressed in neurons during maturation and synapse formation. |
| Function | Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage. |
| Peptide Name | Neuronal Vesicle Trafficking-Associated Protein 1 Brain Neuron Cytoplasmic Protein 1/2 Neuron-Enriched Endosomal Protein Of 21 Kda Neuron-Specific Protein Family Member 1 |
| Cellular Localisation | Membrane Single-Pass Type Ii Membrane Protein Golgi Apparatus Trans-Golgi Network Membrane Endosome Membrane Cell Projection Dendrite Early Endosome Membrane Late Endosome Membrane Lysosome Lumen Recycling Endosome Membrane Cytoplasmic Vesicle Membrane Golgi Stack Membrane Endosome Multivesicular Body Membrane Endoplasmic Reticulum Membrane Endocytosed From The Cell Surface Thus Enters Into Early Endosomes Trafficks To Late Endosomes And Degradates In Lysosomes Endoplasmic Reticulum Targeting Is Essential For Apoptosis Found In Both Stationary And Motile Endosomes A Previous Study Supports A Type I Membrane Protein Topology |
| Alternative Peptide Names | Neuronal Vesicle Trafficking-Associated Protein 1 protein Brain Neuron Cytoplasmic Protein 1/2 protein Neuron-Enriched Endosomal Protein Of 21 Kda protein Neuron-Specific Protein Family Member 1 protein Nsg1 protein Bsmrb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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