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產品詳情

  • 產品名稱：CD86 Blocking Peptide for STJ500487 peptide (STJ503837)

  • 產品型號：STJ503837-250
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
CD86 Blocking Peptide for STJ500487 peptide (STJ503837)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CD86 Blocking Peptide for STJ500487 is synthetically produced from the 250-329 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CD86
Gene ID: 942
Uniprot ID: CD86_HUMAN
Immunogen Region: 250-329
Specificity: This blocking peptide is recommended for use in combination with CD86 antibody, STJ500487
Immunogen: Synthetic peptide taken within amino acid region 250-329 on human CD86 protein.
Tissue Specificity Expressed by activated B-lymphocytes and monocytes.
Post Translational Modifications Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Peptide Name T-Lymphocyte Activation Antigen Cd86
Activation B7-2 Antigen
B70
Bu63
Ctla-4 Counter-Receptor B7.2
Fun-1
Cd Antigen Cd86
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-389513
Reactome: R-HSA-6783783
Reactome: R-HSA-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Peptide Names T-Lymphocyte Activation Antigen Cd86 protein
Activation B7-2 Antigen protein
B70 protein
Bu63 protein
Ctla-4 Counter-Receptor B7.2 protein
Fun-1 protein
Cd Antigen Cd86 protein
CD86 protein
CD28LG2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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