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產(chǎn)品詳情

  • 產(chǎn)品名稱：CD8 beta Blocking Peptide for STJ505976 peptide (STJ505748)

  • 產(chǎn)品型號(hào)：STJ505748-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
CD8 beta Blocking Peptide for STJ505976 peptide (STJ505748)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CD8 beta Blocking Peptide for STJ505976 is synthetically produced from the 70-120 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CD8B
Gene ID: 926
Uniprot ID: CD8B_HUMAN
Immunogen Region: 70-120
Specificity: This blocking peptide is recommended for use in combination with CD8 beta antibody, STJ505976
Immunogen: Synthetic peptide taken within amino acid region 70-120 on human T-cell surface glycoprotein CD8 Beta chain.
Post Translational Modifications Phosphorylated as a consequence of T-cell activation. Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.
Peptide Name T-Cell Surface Glycoprotein Cd8 Beta Chain
Cd Antigen Cd8b
Database Links Reactome: R-HSA-182218
Reactome: R-HSA-198933
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Requires The Partner Cd8a For Efficient Cell Surface Expression
The Heterodimer Cd8a/Cd8b Localizes To Lipid Rafts Due To Cd8b Cytoplasmic Tail Palmitoylation
Isoform 2: Cell Membrane
Isoform 3: Secreted
Isoform 4: Cell Membrane
Isoform 5: Cell Membrane
Isoform 6: Secreted
Isoform 7: Secreted
Isoform 8: Secreted
Alternative Peptide Names T-Cell Surface Glycoprotein Cd8 Beta Chain protein
Cd Antigen Cd8b protein
CD8B protein
CD8B1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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