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產(chǎn)品詳情

  • 產(chǎn)品名稱：CD47 Blocking Peptide for STJ507779 peptide (STJ507782)

  • 產(chǎn)品型號：STJ507782-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
CD47 Blocking Peptide for STJ507779 peptide (STJ507782)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CD47 Blocking Peptide for STJ507779 is synthetically produced from the 1-200 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CD47
Gene ID: 961
Uniprot ID: CD47_HUMAN
Immunogen Region: 1-200
Specificity: This blocking peptide is recommended for use in combination with CD47 antibody, STJ507779
Immunogen: Synthetic peptide corresponding to amino acids within region 1-200 on human CD47 protein.
Function Adhesive protein that mediates cell-to-cell interactions. Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering. Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging. In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells.
Peptide Name Leukocyte Surface Antigen Cd47
Antigenic Surface Determinant Protein Oa3
Integrin-Associated Protein
Iap
Protein Mer6
Cd Antigen Cd47
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-391160
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Leukocyte Surface Antigen Cd47 protein
Antigenic Surface Determinant Protein Oa3 protein
Integrin-Associated Protein protein
Iap protein
Protein Mer6 protein
Cd Antigen Cd47 protein
CD47 protein
MER6 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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