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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：CD300 Blocking Peptide peptide (STJ505555)

  • 產(chǎn)品型號(hào)：STJ505555-250
  • 產(chǎn)品廠(chǎng)商：ST john's laboratory
  • 產(chǎn)品文檔：
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CD300 Blocking Peptide peptide (STJ505555)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CD300 Blocking Peptide is synthetically produced from the 230-290 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CD300LF
Gene ID: 146722
Uniprot ID: CLM1_HUMAN
Immunogen Region: 230-290
Immunogen: Synthetic peptide taken within amino acid region 230-290 on human CMRF35-like molecule 1/CD300LF.
Tissue Specificity Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
Post Translational Modifications Phosphorylated on tyrosine.
Function Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.
Peptide Name Cmrf35-Like Molecule 1
Clm-1
Cd300 Antigen-Like Family Member F
Immune Receptor Expressed On Myeloid Cells 1
Irem-1
Immunoglobulin Superfamily Member 13
Igsf13
Nk Inhibitory Receptor
Cd Antigen Cd300f
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Peptide Names Cmrf35-Like Molecule 1 protein
Clm-1 protein
Cd300 Antigen-Like Family Member F protein
Immune Receptor Expressed On Myeloid Cells 1 protein
Irem-1 protein
Immunoglobulin Superfamily Member 13 protein
Igsf13 protein
Nk Inhibitory Receptor protein
Cd Antigen Cd300f protein
CD300LF protein
CD300F protein
CLM1 protein
IGSF13 protein
IREM1 protein
NKIR protein
UNQ3105 protein
PRO10111 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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