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產(chǎn)品名稱(chēng)：Human CD3 epsilon/CD3E protein (Recombinant) (C-His) (STJP002725)
產(chǎn)品型號(hào)：STJP002725
產(chǎn)品廠(chǎng)商：ST john's laboratory
產(chǎn)品文檔：

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Human CD3 epsilon/CD3E protein (Recombinant) (C-His) (STJP002725)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD3 epsilon/CD3E-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Anti-CD3 epsilon/CD3e Antibody at 1:3000 (100 Mu L/well) can bind recombinant Human CD3E, the EC50 of Human CD3E is 0.48 ng/mL.

Gene Symbol:	CD3E
Gene ID:	916
Uniprot ID:	CD3E_HUMAN
Immunogen Region:	Met1-Asp126
Immunogen:	Recombinant Human CD3 epsilon/CD3E Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Asp126) of human CD3 epsilon/CD3e (Accession #NP_000724.1) fused with a 6×His tag at the C-terminus.

Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
Protein Name	T-Cell Surface Glycoprotein Cd3 Epsilon Chain T-Cell Surface Antigen T3/Leu-4 Epsilon Chain Cd Antigen Cd3e
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-389948
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	T-Cell Surface Glycoprotein Cd3 Epsilon Chain protein T-Cell Surface Antigen T3/Leu-4 Epsilon Chain protein Cd Antigen Cd3e protein CD3E protein T3E protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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