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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD28 protein (Recombinant) (N-His & Avi) {Biotin} (STJP002119)

  • 產(chǎn)品型號：STJP002119-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CD28 protein (Recombinant) (N-His & Avi) {Biotin} (STJP002119)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD28-N-His & Avi protein was developed from hek293 cells and has a target region of N-His & Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Immobilized Human/Cynomolgus/Rhesus macaque CD28, His Tag at 0.5 Mu g/mL (100 Mu L/Well) on the plate. Dose response curve for Anti-CD28 Ab, hFc Tag with the EC50 of 17.3 ng/mL determined by ELISA.
Gene Symbol: CD28
Gene ID: 940
Uniprot ID: CD28_HUMAN
Immunogen Region: Thr17-Pro152
Immunogen: Biotinylated Recombinant Human CD28 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Thr17-Pro152) of Human CD28 fused with a His tag and Avi tag at the N-terminal.
Post Translational Modifications CD40LG induces tyrosine phosphorylation of isoform 3.
Function Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Protein Name T-Cell-Specific Surface Glycoprotein Cd28
Tp44
Cd Antigen Cd28
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-164939
Reactome: R-HSA-2219530
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-6811558
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Isoform 3: Cell Surface
Alternative Protein Names T-Cell-Specific Surface Glycoprotein Cd28 protein
Tp44 protein
Cd Antigen Cd28 protein
CD28 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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