產(chǎn)品詳情
簡單介紹：
Anti-Acetyl-H1-4-K26 antibody (STJ11103882)
詳情介紹：
| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-Histone H1.4-K26 is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | H1-4 |
| Gene ID: | 3008 |
| Uniprot ID: | H14_HUMAN |
| Immunogen: | A synthetic acetylated peptide around K26 of human Histone H14 (NP_005312.1). |
| Immunogen Sequence: | ARKSA |
| Post Translational Modifications | H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1. Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. ADP-ribosylated on Ser-150 in response to DNA damage. |
| Function | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. |
| Protein Name | Histone H1.4 Histone H1b Histone H1s-4 |
| Database Links | Reactome: R-HSA-140342 Reactome: R-HSA-2559584 |
| Cellular Localisation | Nucleus Chromosome Mainly Localizes In Heterochromatin Dysplays A Punctuate Staining Pattern In The Nucleus |
| Alternative Antibody Names | Anti-Histone H1.4 antibody Anti-Histone H1b antibody Anti-Histone H1s-4 antibody Anti-H1-4 antibody Anti-H1F4 antibody Anti-HIST1H1E antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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