產品詳情
簡單介紹：
Anti-Acetyl-E2F4-Lys96 antibody (61-110 aa) (STJ90140)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Acetyl-Transcription factor E2F4-Lys96 (61-110 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | E2F4 |
| Gene ID: | 1874 |
| Uniprot ID: | E2F4_HUMAN |
| Immunogen Region: | 61-110 aa |
| Specificity: | Acetyl-E2F-4 (K96) Polyclonal Antibody detects endogenous levels of E2F-4 protein only when acetylated at K96. |
| Immunogen: | The antiserum was produced against synthesized Acetyl-peptide derived from the human E2F4 around the Acetylation site of Lys96 at the amino acid range 61-110 |
| Post Translational Modifications | Differentially phosphorylated in vivo. |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. |
| Protein Name | Transcription Factor E2f4 E2f-4 |
| Database Links | Reactome: R-HSA-1362277 Reactome: R-HSA-1362300 Reactome: R-HSA-1538133 Reactome: R-HSA-2173796 Reactome: R-HSA-6804114 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69656 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor E2f4 antibody Anti-E2f-4 antibody Anti-E2F4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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