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產(chǎn)品詳情

  • 產(chǎn)品名稱：CCR5 Blocking Peptide peptide (STJ503785)

  • 產(chǎn)品型號：STJ503785-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
CCR5 Blocking Peptide peptide (STJ503785)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CCR5 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CCR5
Gene ID: 1234
Uniprot ID: CCR5_HUMAN
Immunogen Region: 1-50 aa
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.
Tissue Specificity Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Post Translational Modifications Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
Function Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Peptide Name C-C Chemokine Receptor Type 5
C-C Ckr-5
Cc-Ckr-5
Ccr-5
Ccr5
Chemr13
Hiv-1 Fusion Coreceptor
Cd Antigen Cd195
Database Links Reactome: R-HSA-173107
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names C-C Chemokine Receptor Type 5 protein
C-C Ckr-5 protein
Cc-Ckr-5 protein
Ccr-5 protein
Ccr5 protein
Chemr13 protein
Hiv-1 Fusion Coreceptor protein
Cd Antigen Cd195 protein
CCR5 protein
CMKBR5 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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