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簡單介紹：

CCK4/PTK7 Positive Control peptide (STJ503818)

詳情介紹：

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CCK4/PTK7 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:500
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	MAP3K12
Gene ID:	7786
Uniprot ID:	M3K12_HUMAN
Immunogen:	Purified Protein tyrosine kinase 7 protein was emulsified in complete adjuvant and used to immunize the rabbits.

Tissue Specificity	Highly expressed in brain and kidney.
Post Translational Modifications	Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.
Function	Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
Peptide Name	Mitogen-Activated Protein Kinase Kinase Kinase 12 Dual Leucine Zipper Bearing Kinase Dlk Leucine-Zipper Protein Kinase Zpk Mapk-Upstream Kinase Muk Mixed Lineage Kinase
Cellular Localisation	Cytoplasm Cell Membrane Behaves Essentially As An Integral Membrane Protein
Alternative Peptide Names	Mitogen-Activated Protein Kinase Kinase Kinase 12 protein Dual Leucine Zipper Bearing Kinase protein Dlk protein Leucine-Zipper Protein Kinase protein Zpk protein Mapk-Upstream Kinase protein Muk protein Mixed Lineage Kinase protein MAP3K12 protein ZPK protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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