產品詳情
簡單介紹:
CCK4 Blocking Peptide peptide (STJ503779)
詳情介紹:
Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | CCK4 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | MAP3K12 |
Gene ID: | 7786 |
Uniprot ID: | M3K12_HUMAN |
Immunogen: | Purified Protein tyrosine kinase 7 protein was emulsified in complete adjuvant and used to immunize the rabbits. |
Tissue Specificity | Highly expressed in brain and kidney. |
Post Translational Modifications | Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. |
Function | Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. |
Peptide Name | Mitogen-Activated Protein Kinase Kinase Kinase 12 Dual Leucine Zipper Bearing Kinase Dlk Leucine-Zipper Protein Kinase Zpk Mapk-Upstream Kinase Muk Mixed Lineage Kinase |
Cellular Localisation | Cytoplasm Cell Membrane Behaves Essentially As An Integral Membrane Protein |
Alternative Peptide Names | Mitogen-Activated Protein Kinase Kinase Kinase 12 protein Dual Leucine Zipper Bearing Kinase protein Dlk protein Leucine-Zipper Protein Kinase protein Zpk protein Mapk-Upstream Kinase protein Muk protein Mixed Lineage Kinase protein MAP3K12 protein ZPK protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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