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簡單介紹：

CCDC98 Positive Control for STJ500026 peptide (STJ503618)

詳情介紹：

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CCDC98 Positive Control for STJ500026 is synthetically produced from the sequence and is suitable for use in western blot applications.

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	ABRAXAS1
Gene ID:	84142
Uniprot ID:	ABRX1_HUMAN
Specificity:	This is positive control is recommended for use in combination with CCDC98 antibody STJ500026.

Post Translational Modifications	Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage.
Function	Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Peptide Name	Brca1-A Complex Subunit Abraxas 1 Coiled-Coil Domain-Containing Protein 98 Protein Fam175a
Database Links	Reactome: R-HSA-5689901 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-69473
Cellular Localisation	Nucleus Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Alternative Peptide Names	Brca1-A Complex Subunit Abraxas 1 protein Coiled-Coil Domain-Containing Protein 98 protein Protein Fam175a protein ABRAXAS1 protein ABRA1 protein CCDC98 protein FAM175A protein UNQ496 protein PRO1013 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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