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產(chǎn)品詳情

  • 產(chǎn)品名稱：CCDC98 Blocking Peptide for STJ500022 peptide (STJ503617)

  • 產(chǎn)品型號(hào)：STJ503617-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
CCDC98 Blocking Peptide for STJ500022 peptide (STJ503617)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CCDC98 Blocking Peptide for STJ500022 is synthetically produced from the 350-400 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ABRAXAS1
Gene ID: 84142
Uniprot ID: ABRX1_HUMAN
Immunogen Region: 350-400
Specificity: This blocking peptide is recommended for use in combination with CCDC98 antibody, STJ500022
Immunogen: Synthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein.
Post Translational Modifications Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage.
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Peptide Name Brca1-A Complex Subunit Abraxas 1
Coiled-Coil Domain-Containing Protein 98
Protein Fam175a
Database Links Reactome: R-HSA-5689901
Reactome: R-HSA-5693565
Reactome: R-HSA-5693571
Reactome: R-HSA-5693607
Reactome: R-HSA-69473
Cellular Localisation Nucleus
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Alternative Peptide Names Brca1-A Complex Subunit Abraxas 1 protein
Coiled-Coil Domain-Containing Protein 98 protein
Protein Fam175a protein
ABRAXAS1 protein
ABRA1 protein
CCDC98 protein
FAM175A protein
UNQ496 protein
PRO1013 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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