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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD119 (IFNGR1) protein (Recombinant) (STJP000438)

  • 產(chǎn)品型號：STJP000438
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CD119 (IFNGR1) protein (Recombinant) (STJP000438)
詳情介紹：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD119 (IFNGR1)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: 0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Gene Symbol: IFNGR1
Gene ID: 3459
Uniprot ID: INGR1_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Human IFN-gamma receptor (IFNGR1) including a C-terminal 6His tag was expressed in HEK293 cells. NA
Post Translational Modifications Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-457 is required for IFNG receptor signal transduction. Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner. Ubiquitinated after phosphorylation in a CSNK1A1-dependent manner, leading to the lysosome-dependent degradation. Proteasomally degraded through 'Lys-48'-mediated ubiquitination. Ubiquitination is necessary for efficient IFNGR1 signaling.
Function Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Protein Name Interferon Gamma Receptor 1
Ifn-Gamma Receptor 1
Ifn-Gamma-R1
Cdw119
Interferon Gamma Receptor Alpha-Chain
Ifn-Gamma-R-Alpha
Cd Antigen Cd119
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-9679191
Reactome: R-HSA-9732724
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interferon Gamma Receptor 1 protein
Ifn-Gamma Receptor 1 protein
Ifn-Gamma-R1 protein
Cdw119 protein
Interferon Gamma Receptor Alpha-Chain protein
Ifn-Gamma-R-Alpha protein
Cd Antigen Cd119 protein
IFNGR1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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