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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Human CD114 (GCSFR) protein (Recombinant) (STJP000675)

  • 產(chǎn)品型號(hào)：STJP000675
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Human CD114 (GCSFR) protein (Recombinant) (STJP000675)
詳情介紹：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD114 (GCSFR)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: 0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Immunoreactivity: The activity of Recombinant human CD114 was measured by its ability to inhibit the G-CSF induced proliferation of NFS60 mouse myeloid cells. The ED50 for this effect is typically 20-80 ng/mL. NA
Gene Symbol: CSF3R
Gene ID: 1441
Uniprot ID: CSF3R_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of human CD114 including a C-terminal 6His tag was expressed in HEK293 cells. NA
Tissue Specificity One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.
Post Translational Modifications N-glycosylated.
Function Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
Protein Name Granulocyte Colony-Stimulating Factor Receptor
G-Csf Receptor
G-Csf-R
Cd Antigen Cd114
Database Links Reactome: R-HSA-449836
Reactome: R-HSA-9616222
Reactome: R-HSA-9674555
Reactome: R-HSA-9705462
Cellular Localisation Isoform 2: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Granulocyte Colony-Stimulating Factor Receptor protein
G-Csf Receptor protein
G-Csf-R protein
Cd Antigen Cd114 protein
CSF3R protein
GCSFR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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