產(chǎn)品詳情
簡單介紹：
Human CD113 (Nectin-3) protein (Recombinant) (STJP000694)
詳情介紹：
| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human CD113 (Nectin-3)-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | 0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1EU/μg). NA |
| Immunoreactivity: | The activity of Recombinant human CD113 was measured in a functional ELISA assay, immobilized recombinant human CD113 at 1 Mu g/ml ( 100 Mu l/well ) can bind biotinylated Nectin-1 with a linear range of 6-800 Mu g/ml NA |
| Gene Symbol: | NECTIN3 |
| Gene ID: | 25945 |
| Uniprot ID: | NECT3_HUMAN |
| Immunogen Region: | ECD |
| Immunogen: | Optimized DNA sequence encoding extracellular domain of human CD113 (nectin-3) including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
| Function | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. |
| Protein Name | Nectin-3 Cdw113 Nectin Cell Adhesion Molecule 3 Poliovirus Receptor-Related Protein 3 Cd Antigen Cd113 |
| Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-420597 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Postsynaptic Cell Membrane |
| Alternative Protein Names | Nectin-3 protein Cdw113 protein Nectin Cell Adhesion Molecule 3 protein Poliovirus Receptor-Related Protein 3 protein Cd Antigen Cd113 protein NECTIN3 protein PRR3 protein PVRL3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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