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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human CD106 (VCAM1) protein (Recombinant) (STJP000467)

  • 產(chǎn)品型號：STJP000467
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human CD106 (VCAM1) protein (Recombinant) (STJP000467)
詳情介紹：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD106 (VCAM1)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: 0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/μg (1EU/μg). NA
Immunoreactivity: The activity of recombinant VCAM1 was tested by immobilized recombinant CD106 (10ug/ml) ability to support adhesion of U937 human histiocytic lymphoma cells (5x104 cells/well ) , 70% will adhere after 60min at 37C. NA
Gene Symbol: VCAM1
Gene ID: 7412
Uniprot ID: VCAM1_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding Human extracellular domain of human CD106including a C-terminal 6His tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Post Translational Modifications Cleaved by the metalloproteinase ADAM17 to generate the soluble form. Sialoglycoprotein. Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination.leading to proteasomal degradation.
Function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.
Protein Name Vascular Cell Adhesion Protein 1
V-Cam 1
Vcam-1
Incam-100
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-216083
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Cellular Localisation Vascular Cell Adhesion Protein 1: Cell Membrane
Single-Pass Type I Membrane Protein
Soluble Vascular Cell Adhesion Molecule-1: Secreted
Alternative Protein Names Vascular Cell Adhesion Protein 1 protein
V-Cam 1 protein
Vcam-1 protein
Incam-100 protein
Cd Antigen Cd106 Cleaved Into - Soluble Vascular Cell Adhesion Molecule-1 protein
VCAM1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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