產(chǎn)品詳情
簡單介紹：
Human CD10/MME protein (Recombinant) (C-His) (STJP002446)
詳情介紹：
| Host: | HEK293 Cells |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human CD10/MME-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of 20mM MES, 100mM NaCl, 1mM ZnCl2, 10%Glycerol, pH 6.5. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, (R&D Systems, Catalog # ES005). The specific activity is >1, 500 pmoles/min/Mu g. |
| Gene Symbol: | MME |
| Gene ID: | 4311 |
| Uniprot ID: | NEP_HUMAN |
| Immunogen Region: | Tyr52-Trp750 |
| Immunogen: | Recombinant Human CD10/MME Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Tyr52-Trp750) of human CD10/MME (Accession #NP_000893.2) fused with a 6×His tag at the C-terminus. |
| Function | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. |
| Protein Name | Neprilysin Atriopeptidase Common Acute Lymphocytic Leukemia Antigen Calla Enkephalinase Neutral Endopeptidase 24.11 Nep Neutral Endopeptidase Skin Fibroblast Elastase Sfe Cd Antigen Cd10 |
| Database Links | Reactome: R-HSA-2022377 Reactome: R-HSA-5578768 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Neprilysin protein Atriopeptidase protein Common Acute Lymphocytic Leukemia Antigen protein Calla protein Enkephalinase protein Neutral Endopeptidase 24.11 protein Nep protein Neutral Endopeptidase protein Skin Fibroblast Elastase protein Sfe protein Cd Antigen Cd10 protein MME protein EPN protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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