產(chǎn)品詳情
簡單介紹：
Human CCL2/MCP-1 protein (Recombinant) (No tag) (STJP001403)
詳情介紹：
| Host: | E. coli |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human CCL2/MCP-1-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: | Measured by the ability to inhibit the proliferation of HUVEC (Human Umbilical Vein Endothelial Cells). The ED50 for this effect is 0.53-2.12 ng/mL.2. Measured by its ability to chemoattract THP-1 cells. The ED50 for this effect is typically 1.01-4.0 |
| Gene Symbol: | CCL2 |
| Gene ID: | 6347 |
| Uniprot ID: | CCL2_HUMAN |
| Immunogen: | Active Recombinant Human CCL2/MCP-1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Gln24-Thr99) of human CCL2/MCP-1 (Accession #NP_002973.1) fused with no additional amino acid. |
| Post Translational Modifications | Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| Protein Name | C-C Motif Chemokine 2 Hc11 Monocyte Chemoattractant Protein 1 Monocyte Chemotactic And Activating Factor Mcaf Monocyte Chemotactic Protein 1 Mcp-1 Monocyte Secretory Protein Je Small-Inducible Cytokine A2 |
| Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-380994 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 2 protein Hc11 protein Monocyte Chemoattractant Protein 1 protein Monocyte Chemotactic And Activating Factor protein Mcaf protein Monocyte Chemotactic Protein 1 protein Mcp-1 protein Monocyte Secretory Protein Je protein Small-Inducible Cytokine A2 protein CCL2 protein MCP1 protein SCYA2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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