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產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：Human Cathepsin L protein (Recombinant) (C-His) (STJP002445)

  • 產(chǎn)品型號(hào)：STJP002445-50
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Human Cathepsin L protein (Recombinant) (C-His) (STJP002445)
詳情介紹：
Host: HEK293 Cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Cathepsin L-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of 50 mM NaAc, 100 mM NaCl, pH 7.5.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CTSL
Gene ID: 1514
Uniprot ID: CATL1_HUMAN
Immunogen Region: Thr18-Val333
Immunogen: Recombinant Human Cathepsin L Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Thr18-Val333) of human Cathepsin L (Accession #NP_001903.1) fused with a 6×His tag at the C-terminus.
Function Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter. In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation. Secreted form generates endostatin from COL18A1. Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation. Required for maximal stimulation of steroidogenesis by TIMP1. (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell. Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins. Isoform 2: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor. Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties.
Protein Name Procathepsin L
Cathepsin L1
Major Excreted Protein
Mep Cleaved Into - Cathepsin L - Cathepsin L Heavy Chain - Cathepsin L Light Chain
Database Links Reactome: R-HSA-1236977
Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-1679131
Reactome: R-HSA-2022090
Reactome: R-HSA-2132295
Reactome: R-HSA-8939242
Reactome: R-HSA-9678110
Reactome: R-HSA-9694614
Cellular Localisation Lysosome
Apical Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule
Secreted
Extracellular Space
Localizes To The Apical Membrane Of Thyroid Epithelial Cells
Released At Extracellular Space By Activated Dendritic Cells And Macrophages
Isoform 2: Nucleus
Translation Initiation At Downstream Start Sites Allows The Synthesis Of Isoforms That Are Devoid Of A Signal Peptide And Do Not Transit Through The Endoplasmic Reticulum To Localize To The Nucleus
Nuclear Location Varies During The Cell Cycle
With Higher Levels During S Phase
Alternative Protein Names Procathepsin L protein
Cathepsin L1 protein
Major Excreted Protein protein
Mep Cleaved Into - Cathepsin L - Cathepsin L Heavy Chain - Cathepsin L Light Chain protein
CTSL protein
CTSL1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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