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產(chǎn)品詳情
  • 產(chǎn)品名稱:Anti-ACACB antibody (STJ195868)

  • 產(chǎn)品型號(hào):STJ195868
  • 產(chǎn)品廠商:ST john's laboratory
  • 產(chǎn)品文檔:
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簡(jiǎn)單介紹:
Anti-ACACB antibody (STJ195868)
詳情介紹:
Host: Rabbit
Applications: WB
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Acetyl-CoA carboxylase 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACACB
Gene ID: 32
Uniprot ID: ACACB_HUMAN
Specificity: This antibody detects endogenous levels of ACACB at Human
Immunogen: Synthesized peptide derived from the human ACACB
Post Translational Modifications The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. Phosphorylation at Ser-222 by AMPK inactivates the enzyme. Required for the maintenance of skeletal muscle lipid and glucose homeostasis.
Function Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism. Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation. Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage.
Protein Name Acetyl-Coa Carboxylase 2
Acc-Beta
Database Links Reactome: R-HSA-163765
Reactome: R-HSA-196780
Reactome: R-HSA-200425
Reactome: R-HSA-2426168
Cellular Localisation Mitochondrion
Alternative Antibody Names Anti-Acetyl-Coa Carboxylase 2 antibody
Anti-Acc-Beta antibody
Anti-ACACB antibody
Anti-ACC2 antibody
Anti-ACCB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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