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Human B7-H2/ICOSLG/CD275 protein (Recombinant) (C-His) (STJP002721)

詳情介紹：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human B7-H2/ICOSLG/CD275-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2/ICOSLG at 1 Mu g/mL (100 Mu L/well) can bind Human ICOS/CD278 with a linear range of 2-14.8 ng/mL.

Gene Symbol:	ICOSLG
Gene ID:	23308
Uniprot ID:	ICOSL_HUMAN
Immunogen Region:	Asp19-Ser258
Immunogen:	Recombinant Human B7-H2/ICOSLG/CD275 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp19-Ser258) of human B7-H2/ICOSLG (Accession #NP_056074.1) fused with a 6×His tag at the C-terminus.

Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion.induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
Protein Name	Icos Ligand B7 Homolog 2 B7-H2 B7-Like Protein Gl50 B7-Related Protein 1 B7rp-1 Cd Antigen Cd275
Database Links	Reactome: R-HSA-388841
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Icos Ligand protein B7 Homolog 2 protein B7-H2 protein B7-Like Protein Gl50 protein B7-Related Protein 1 protein B7rp-1 protein Cd Antigen Cd275 protein ICOSLG protein B7H2 protein B7RP1 protein ICOSL protein KIAA0653 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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