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產(chǎn)品詳情

  • 產(chǎn)品名稱：Human Angiotensinogen/AGT protein (Recombinant) (C-His) (STJP001103)

  • 產(chǎn)品型號(hào)：STJP001103
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Human Angiotensinogen/AGT protein (Recombinant) (C-His) (STJP001103)
詳情介紹：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Angiotensinogen/AGT-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human Angiotensinogen at 1 Mu g/mL (100 Mu L/well) can bind Anti-Angiotensinogen rabbit Mab with a linear range of 0.78-2.44 ng/mL.
Gene Symbol: AGT
Gene ID: 183
Uniprot ID: ANGT_HUMAN
Immunogen: Recombinant Human Angiotensinogen/AGT Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp 34-Ala 485 ) of human Angiotensinogen (Accession #NP_000020.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Expressed by the liver and secreted in plasma.
Post Translational Modifications Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor. In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
Function Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor. Angiotensin-3: Stimulates aldosterone release. Angiotensin 1-7: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Protein Name Angiotensinogen
Serpin A8 Cleaved Into - Angiotensin-1
Angiotensin 1-10
Angiotensin I
Ang I - Angiotensin-2
Angiotensin 1-8
Angiotensin Ii
Ang Ii - Angiotensin-3
Angiotensin 2-8
Angiotensin Iii
Ang Iii
Des-Asp1-Angiotensin Ii - Angiotensin-4
Angiotensin 3-8
Angiotensin Iv
Ang Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2022377
Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-418594
Cellular Localisation Secreted
Alternative Protein Names Angiotensinogen protein
Serpin A8 Cleaved Into - Angiotensin-1 protein
Angiotensin 1-10 protein
Angiotensin I protein
Ang I - Angiotensin-2 protein
Angiotensin 1-8 protein
Angiotensin Ii protein
Ang Ii - Angiotensin-3 protein
Angiotensin 2-8 protein
Angiotensin Iii protein
Ang Iii protein
Des-Asp1-Angiotensin Ii - Angiotensin-4 protein
Angiotensin 3-8 protein
Angiotensin Iv protein
Ang Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4 protein
AGT protein
SERPINA8 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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