產(chǎn)品詳情
簡單介紹：
Anti-ABCG1 antibody (100-200) [S1MR] (STJ11101451)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-ABCG1 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S1MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCG1 |
| Gene ID: | 9619 |
| Uniprot ID: | ABCG1_HUMAN |
| Immunogen Region: | 100-200 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABCG1 (NP_004906.3). |
| Immunogen Sequence: | LLKGISGKFNSGELVAIMGP SGAGKSTLMNILAGYRETGM KGAVLINGLPRDLRCFRKVS CYIMQDDMLLPHLTVQEAMM VSAHLKLQEKDEGRREMVKE I |
| Tissue Specificity | Expressed in several tissues. Expressed in macrophages.expression is increased in macrophages from patients with Tangier disease. |
| Post Translational Modifications | Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. |
| Function | Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 1 Atp-Binding Cassette Transporter 8 White Protein Homolog |
| Database Links | Reactome: R-HSA-1369062 Reactome: R-HSA-8964058 Reactome: R-HSA-9029569 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane Cell Membrane Predominantly Localized In The Intracellular Compartments Mainly Associated With The Endoplasmic Reticulum (Er) And Golgi Membranes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 1 antibody Anti-Atp-Binding Cassette Transporter 8 antibody Anti-White Protein Homolog antibody Anti-ABCG1 antibody Anti-ABC8 antibody Anti-WHT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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