產(chǎn)品詳情
簡(jiǎn)單介紹：
B-raf Blocking Peptide peptide (STJ505403)
詳情介紹：
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | B-raf Blocking Peptide is synthetically produced from the 700-750 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Dilution Range: | WB: ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | BRAF |
| Gene ID: | 673 |
| Uniprot ID: | BRAF_HUMAN |
| Immunogen Region: | 700-750 |
| Immunogen: | Synthetic peptide taken within amino acid region 700-750 on human serine/threonine-protein kinase B-raf protein. |
| Tissue Specificity | Brain and testis. |
| Post Translational Modifications | Phosphorylation at Ser-365 by SGK1 inhibits its activity. Methylation at Arg-671 decreases stability and kinase activity. Ubiquitinated by RNF149.which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF. |
| Function | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2. May play a role in the postsynaptic responses of hippocampal neurons. |
| Peptide Name | Serine/Threonine-Protein Kinase B-Raf Proto-Oncogene B-Raf P94 V-Raf Murine Sarcoma Viral Oncogene Homolog B1 |
| Database Links | Reactome: R-HSA-1295596 Reactome: R-HSA-170968 Reactome: R-HSA-170984 Reactome: R-HSA-187706 Reactome: R-HSA-5673000 Reactome: R-HSA-5674135 Reactome: R-HSA-5674499 Reactome: R-HSA-5675221 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9726840 Reactome: R-HSA-9726842 |
| Cellular Localisation | Nucleus Cytoplasm Cell Membrane Colocalizes With Rgs14 And Raf1 In Both The Cytoplasm And Membranes |
| Alternative Peptide Names | Serine/Threonine-Protein Kinase B-Raf protein Proto-Oncogene B-Raf protein P94 protein V-Raf Murine Sarcoma Viral Oncogene Homolog B1 protein BRAF protein BRAF1 protein RAFB1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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