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產(chǎn)品詳情

  • 產(chǎn)品名稱：Axin 2 Blocking Peptide peptide (STJ503690)

  • 產(chǎn)品型號(hào)：STJ503690-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Axin 2 Blocking Peptide peptide (STJ503690)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Axin 2 Blocking Peptide is synthetically produced from the 800-843 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: AXIN2
Gene ID: 8313
Uniprot ID: AXIN2_HUMAN
Immunogen Region: 800-843
Immunogen: Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.
Tissue Specificity Expressed in brain and lymphoblast.
Post Translational Modifications Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Peptide Name Axin-2
Axin-Like Protein
Axil
Axis Inhibition Protein 2
Conductin
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4411364
Reactome: R-HSA-4641257
Reactome: R-HSA-5689880
Cellular Localisation Cytoplasm
Alternative Peptide Names Axin-2 protein
Axin-Like Protein protein
Axil protein
Axis Inhibition Protein 2 protein
Conductin protein
AXIN2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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