This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.

Target	Alpha-Centractin (ACTR1A)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 98-126 amino acids from the Central region of human ACTR1A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P61163 (UniProt, ExPASy)
UniProt Secondary AC	B2R6B0, P42024
UniProt Entry Name	ACTZ_HUMAN
KEGG	hsa:10121
String	9606.ENSP00000358921
Molecular Weight	Calculated MW: 42.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat and Monkey ACTR1A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Alpha-Centractin (ACTR1A)