Alpha Synuclein (SNCA) Antibody is a Mouse Monoclonal antibody for the detection of alpha-synuclein.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Target	Alpha Synuclein (SNCA)
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	synuclein, alpha (non A4 component of amyloid precursor)
Isotype	IgG1
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P37840 (UniProt, ExPASy)
UniProt Secondary AC	A8K2A4, Q13701, Q4JHI3, Q6IAU6
Gene Symbol	SNCA
GeneID	6622
OMIM	127750
HGNC	11138
Ensembl	ENSG00000145335
Molecular Weight	Observed MW: 18 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Alpha Synuclein (SNCA)