Alpha-2-Macroglobulin (A2M) Antibody is a Rabbit Polyclonal antibody for the detection of Alpha-2-macroglobulin.

Alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.

Target	Alpha-2-Macroglobulin (A2M)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	alpha-2-macroglobulin
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P01023 (UniProt, ExPASy)
UniProt Secondary AC	Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
UniProt Entry Name	A2MG_HUMAN
Gene Symbol	A2M
GeneID	2
OMIM	103950
HGNC	7
KEGG	hsa:2
Ensembl	ENSG00000175899
String	9606.ENSP00000323929
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Alpha-2-Macroglobulin (A2M)