Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, 1B and 1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This protein encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This protein comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Target	Alpha 1B Adrenergic Receptor (ADRA1B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 270-297 amino acids from the Central region of human ADRA1B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35368 (UniProt, ExPASy)
UniProt Secondary AC	B0LPE1
UniProt Entry Name	ADA1B_HUMAN
Gene Symbol	ADRA1B
KEGG	hsa:147
String	9606.ENSP00000306662
Molecular Weight	Calculated MW: 56.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Rabbit ADRA1B.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Alpha 1B Adrenergic Receptor (ADRA1B)