AKR1B1 Antibody is a Rabbit Polyclonal antibody against AKR1B1. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009].

Target	Aldose Reductase (AKR1B1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P15121 (UniProt, ExPASy)
UniProt Secondary AC	B2R8N3, Q5U031, Q6FGA4, Q6ICP2, Q9BS21, Q9UCI9
UniProt Entry Name	ALDR_HUMAN
Gene Symbol	AKR1B1
GeneID	231
OMIM	103880
NCBI Accession	NP_001619.1
HGNC	381
KEGG	hsa:231
Ensembl	ENSG00000085662
String	9606.ENSP00000285930
Enzyme Commission Number	EC 1.1.1.21
Molecular Weight	Calculated MW: 36 kDa Observed MW: 36 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	1.03 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Aldose Reductase (AKR1B1)