Advanced Glycation End Products (AGEs) are the result of a chain of chemical reactions after an initial glycation reaction. Glycation is accomplished by the Maillard reaction, which is a multistep process that begins with Schiff base formation between the amine and the carbonyl group on the sugar followed by rearrangement to form Amadori intermediates. AGEs affect nearly every type of cell and molecule in the body, and are thought to be one factor in aging and some age-related chronic diseases. They are also believed to play a causative role in the vascular complications of diabetes mellitus.

This product is the immunogen for the following antibodies: abx102967, abx131709

Target	Advanced Glycation End Product (AGE)
Origin	General
Expression	Native
Tested Applications	WB, SDS-PAGE
Conjugation	Unconjugated
Form	Lyophilized
Purity	> 90%
Purification	Purified by salt co-precipitation and ion exchange chromatography.
Reconstitution	To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Storage	Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Molecular Weight	Calculated MW: 68.0 kDa Observed MW: 68.0 kDa
Sequence	This product is a native protein and the sequence has not been determined.
Buffer	Prior to lyophilization: PBS, pH 7.4, containing 5% Trehalose.
Activity	Not tested
Concentration	Prior to lyophilization: 10 mg/ml
Availability	Shipped within 5-7 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on Advanced Glycation End Product (AGE)