ADAMTS4 Antibody is a Rabbit Polyclonal antibody against ADAMTS4. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Target	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 74-318 of human ADAMTS4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75173 (UniProt, ExPASy)
UniProt Secondary AC	Q2HYD0, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83
UniProt Entry Name	ATS4_HUMAN
Gene Symbol	ADAMTS4
GeneID	9507
NCBI Accession	NP_005090.3
KEGG	hsa:9507
String	9606.ENSP00000356975
Molecular Weight	Calculated MW: 90 kDa Observed MW: 90 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4)