ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.

Target	ADAM Metallopeptidase Domain 17 (ADAM17)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 195-224 amino acids from the N-terminal region of human ADAM17.
Isotype	IgG
Form	Liquid
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, then purified by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P78536 (UniProt, ExPASy)
UniProt Secondary AC	O60226
UniProt Entry Name	ADA17_HUMAN
KEGG	hsa:6868
String	9606.ENSP00000309968
Molecular Weight	Calculated MW: 93 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ADAM Metallopeptidase Domain 17 (ADAM17)