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產(chǎn)品詳情

  • 產(chǎn)品名稱：ACK1 (pY518) Antibody

  • 產(chǎn)品型號：abx032041
  • 產(chǎn)品廠商：abbexa
  • 產(chǎn)品文檔：
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簡單介紹：
ACK1 (pY518) Antibody
詳情介紹：
ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.

Target ACK1 (pY518)
Clonality Polyclonal
Target Modification Tyr518
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, DB
Host Rabbit
Recommended dilutions DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y518 of human ACK1.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q07912 (UniProt, ExPASy)
UniProt Secondary AC Q6ZMQ0, Q8N6U7, Q96H59
UniProt Entry Name ACK1_HUMAN
KEGG hsa:10188
String 9606.ENSP00000371341
Molecular Weight Calculated MW: 115 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Cow TNK2.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ACK1 (pY518)
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