This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.

Target	A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 210-240 amino acids from the N-terminal region of human ADAMTS10.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H324 (UniProt, ExPASy)
UniProt Secondary AC	M0QZE4
UniProt Entry Name	ATS10_HUMAN
Gene Symbol	ADAMTS10
String	9606.ENSP00000270328
Molecular Weight	Calculated MW: 121 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10)