INPP5E Antibody is a Rabbit Monoclonal antibody against INPP5E. The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Target	72 kDa Inositol Polyphosphate 5-Phosphatase (INPP5E)
Clonality	Monoclonal
Reactivity	Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CD81.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NRR6 (UniProt, ExPASy)
UniProt Secondary AC	Q15734, Q6PIV5
UniProt Entry Name	INP5E_HUMAN
GeneID	56623
String	9606.ENSP00000360777
Molecular Weight	Calculated MW: 26 kDa Observed MW: 22 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 0.05% BSA, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 72 kDa Inositol Polyphosphate 5-Phosphatase (INPP5E)