The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.

Target	5-Hydroxytryptamine Receptor 1B (HTR1B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 225-253 amino acids from the Central region of human HTR1B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28222 (UniProt, ExPASy)
UniProt Secondary AC	Q4VAY7
UniProt Entry Name	5HT1B_HUMAN
Gene Symbol	HTR1B
KEGG	hsa:3351
String	9606.ENSP00000358963
Molecular Weight	Calculated MW: 43.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Pig and Horse HTR1B.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 5-Hydroxytryptamine Receptor 1B (HTR1B)