5'-AMP-Activated Protein Kinase Subunit Gamma-1 (PRKAG1) Antibody is a Rabbit Polyclonal antibody for the detection of 5'-AMP-Activated Protein Kinase Subunit Gamma-1.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Target	5'-AMP-Activated Protein Kinase Subunit Gamma-1 (PRKAG1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P54619 (UniProt, ExPASy)
UniProt Secondary AC	B4DDT7, Q8N7V9
UniProt Entry Name	AAKG1_HUMAN
Gene Symbol	PRKAG1
GeneID	5571
OMIM	602742
HGNC	9385
KEGG	hsa:5571
Ensembl	ENSG00000181929
String	9606.ENSP00000323867
Molecular Weight	Observed MW: 35-40 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on 5'-AMP-Activated Protein Kinase Subunit Gamma-1 (PRKAG1)